Background and Aims Headache is one of the most common problems in adults and almost 47% of the world's population suffer from some kind of headache. High percentage of these headaches come from neck muscles these are called cervicogenic headaches. The purpose of this study is Comparison of the effect of comprehensive therapeutic protocol with and without manual treatment and kinesiotaping on pain and disability, postural and electrical activity of some neck muscles in men with non-traumatic cervicogenic headache. Methods 43 men aged 35 to 55 years with non-traumatic cervicogenic headache were selected for this study and randomly divided into four groups.Forward head angle, pain and disability and power of neck superficial muscle activation measured by using the photogrammetry, neck pain and disability scale (NPDS) and surface electromyography respectively in pre-test and after six weeks in post-test. Statistical methods, Shapiro-wilk and then repeated measures ANOVA and one-way ANOVA and paired t-test, repeated measure variance and finally and Bonferroni were used (α≤0.05). Results The results showed a significant decrease in pain and disability, forward head angle and also a decrease in the activity of the superficial neck muscles in the experimental groups after six weeks of intervention. (P=0.00). Comparing the above three experimental groups, the comprehensive exercise therapy group with manual therapy had the highest statistical significance in reducing pain and disability, reducing the angle of head forward and reducing the activity of superficial neck muscles. (P=0.00). Conclusion comprehensive exercise therapy intervention with manual therapy had the greatest effect on improving the symptoms of men with non-thromatic cervicogenic headache.