Rational design of highly efficient oxygen evolution reaction (OER) is crucial for the practical application of water electrolysis. Herein, a hybrid Co3O4@FeOOH/NF electrode was fabricated by loading FeOOH sheets on...

Th17 cells producing cytokines, IL-17A and IL-22 are important key player in host defense. We have reported that intestinal epithelial expression of IL-17 receptors in gut epithelial cells control the development of microbiota. To study the roles of these receptors in response to an attaching and effacing pathogen we challenged Citobacter rodenium (C. rodentium) to intestinal epithelial specific IL-17RA or IL-22RA1 KO mice. Conditional deletion of Il17ra or Il22ra1 resulted in increased bacterial growth in the colon as well as enhanced dissemination to the spleen. It suggested both cytokine receptors are required for control of this infection. In addition this was supported by unbiased RNAseq analysis of the colonic epithelium that showed diminished expression of Pigr, Duox2 and Duoxa2 in the absence of IL-17RA signaling and reduced Bcl3 expression in the absence of IL-22ra1 expression. To elucidate whether production from epithelial cells effect bacteria killing we cultured crypt and stimulated IL-17A. It resulted in increasing Pigr, Duoxa2 and Duox2 were associated with increasing bacteria killing. Pigr binds dimeric IgA and translocation into lumen from lamina propria, while Duox2 and Duoxa2 make complex and produce hydrogen peroxide into lumen from apical epithelial cell membrane. These result suggested mucosal immunity to C. rodentium requires both IL-17RA and IL-22ra1 signaling and that IL-17RA regulates transcytosis of C. rodentium specific IgA as well as luminal hydrogen peroxide concentrations to control bacterial growth. In contrast, Il-22Ra1 regulates epithelial Bcl3 expression, which restrains TNFα and NF-κB signaling in the colonic epithelium.

Earth‐abundant metal oxides/hydroxides have recently been identified as promising catalysts for oxygen evolution reaction (OER) in alkaline media, while the overall efficiency is still limited by the sluggish kinetics. Therefore, searching for facile and effective method to prepare composition and morphology tunable catalyst, as well as understanding its reactivity are urgent tasks. Here, we report a hydrothermal etching strategy for the synthesis of Fe doped Co oxides/hydroxide hybrid catalyst with hierarchical nanosheet array architecture. The as‐obtained catalyst shows an overpotential of 219 mV without iR compensation at 10 mA/cm2 and a low Tafel slope of 46.4 mV/dec, surpassing the other control catalysts in this work and most similar catalysts in literature. Comprehensive studies confirm that both composition and morphology can be rationally tuned by adjusting the hydrothermal etching parameters, and the improvement of activity is attributed to the highly active Fe doped Co oxides/hydroxide species together with the unique 3D hierarchical structure.

The Cover Feature shows the oxygen evolution process catalyzed by a hierarchical FeCo oxide/hydroxide catalyst grown on Ni foam, which is prepared by a hydrothermal etching method with FeCo Prussian blue analogue as precursor. Spectroscopic and microscopic investigation demonstrated that the electronic structure of the surface was optimized by Fe doping, and more active sites were exposed with a self‐standing 2D/2D hierarchical structure. The harmony of these two aspects contributes greatly to the outstanding OER catalytic activity. More information can be found in the Research Article by R. Xiang and co‐workers.