Background Sexual and gender minority youth (SGMY; eg, lesbian, gay, bisexual, and transgender youth) are at greater risk than their cisgender heterosexual peers for adolescent relationship abuse (ARA; physical, sexual, or psychological abuse in a romantic relationship). However, there is a dearth of efficacious interventions for reducing ARA among SGMY. To address this intervention gap, we designed a novel web-based methodology leveraging the field of human-centered design to generate multiple ARA intervention concepts with SGMY. Objective This paper aims to describe study procedures for a pilot study to rigorously test the feasibility, acceptability, and appropriateness of using web-based human-centered design methods with SGMY to create novel, stakeholder-driven ARA intervention concepts. Methods We are conducting a longitudinal, web-based human-centered design study with 45-60 SGMY (aged between 14 and 18 years) recruited via social media from across the United States. Using MURAL (a collaborative, visual web-based workspace) and Zoom (a videoconferencing platform), the SGMY will participate in four group-based sessions (1.5 hours each). In session 1, the SGMY will use rose-thorn-bud to individually document their ideas about healthy and unhealthy relationship characteristics and then use affinity clustering as a group to categorize their self-reported ideas based on similarities and differences. In session 2, the SGMY will use rose-thorn-bud to individually critique a universal evidence-based intervention to reduce ARA and affinity clustering to aggregate their ideas as a group. In session 3, the SGMY will use a creative matrix to generate intervention ideas for reducing ARA among them and force-rank the intervention ideas based on their potential ease of implementation and potential impact using an importance-difficulty matrix. In session 4, the SGMY will generate and refine intervention concepts (from session 3 ideations) to reduce ARA using round robin (for rapid iteration) and concept poster (for fleshing out ideas more fully). We will use content analyses to document the intervention concepts. In a follow-up survey, the SGMY will complete validated measures about the feasibility, acceptability, and appropriateness of the web-based human-centered design methods (a priori benchmarks for success: means >3.75 on each 5-point scale). Results This study was funded in February 2020. Data collection began in August 2020 and will be completed by April 2021. Conclusions Through rigorous testing of the feasibility of our web-based human-centered design methodology, our study may help demonstrate the use of human-centered design methods to engage harder-to-reach stakeholders and actively involve them in the co-creation of relevant interventions. Successful completion of this project also has the potential to catalyze intervention research to address ARA inequities for SGMY. Finally, our approach may be transferable to other populations and health topics, thereby advancing prevention science and health equity. International Registered Report Identifier (IRRID) DERR1-10.2196/26554

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BACKGROUND Sexual and gender minority youth (SGMY; e.g., lesbian, gay, bisexual, and transgender youth) are at greater risk than their cisgender heterosexual peers for adolescent relationship abuse (ARA; physical, sexual, or psychological abuse in a romantic relationship). However, there is a death of efficacious interventions for reducing ARA among SGMY. To address this intervention gap, we designed a novel online methodology leveraging the field of human-centered design to have SGMY generate multiple ARA intervention concepts. OBJECTIVE This protocol paper aims to describe study procedures for a pilot study to rigorously test the feasibility, acceptability, and appropriateness for using online human-centered design methods with SGMY to create novel, stakeholder-driven ARA intervention concepts. METHODS We are conducting a longitudinal online human-centered design study with 45-60 SGMY (aged 14-18) recruited via social media from across the U.S. Using MURAL (a collaborative visual online workspace) and Zoom, SGMY participate in 4 group-based sessions (1.5 hours each). In Session 1, SGMY use Rose-Thorn-Bud to individually document their ideas about healthy and unhealthy relationship characteristics, and then use Affinity Clustering as a group to categorize their self-reported ideas by similarities and differences. In Session 2, SGMY use Rose-Thorn-Bud to individually critique a universal evidence-based intervention reducing ARA, and Affinity Clustering to aggregate their ideas as a group. In Session 3, SGMY use a Creative Matrix to generate intervention ideas for reducing ARA among SGMY, and force-ranked the intervention ideas based on their potential ease of implementation and potential impact using an Importance-Difficulty Matrix. In Session 4, SGMY generate and refine intervention concepts (from Session 3 ideations) for reducing ARA using Round Robin (for rapid iteration) and Concept Poster (for fleshing out ideas more fully). We will use content analyses to document the intervention concepts. In a follow-up survey, SGMY complete validated measures about the feasibility, acceptability, and appropriateness of the online human-centered design methods (a priori benchmarks for success: means>3.75 on each 5-point scale). RESULTS The study was funded in February 2020. Data collection started in August 2020, and will be completed by April 2021. CONCLUSIONS By rigorously testing the feasibility of our online human-centered design methodology, our study has the potential to help legitimize the use of human-centered design methods to engage hard-toreach stakeholders in the field of public health and to actively involve them in the co-creation of interventions that may impact them directly. Successful completion of this project also has the potential to catalyze intervention research for addressing ARA inequities for SGMY. Finally, our method can be transported to other populations and health topics, thereby more generally advancing prevention science and health equity.