Bone mineralization of preterm infants is significantly less than full-term infants at birth, placing preterm infants at risk for osteopenia of prematurity and other metabolic bone diseases. Advances in nutritional supplementation and standard nursing care alone have been unsuccessful in improving bone mineralization postnatally. Research supports a daily physical activity protocol of passive range of motion and gentle joint compression when combined with adequate nutritional supplementation reduces osteopenia of prematurity. This article provides a systematic review of the current evidence surrounding early physical activity and neonatal massage for the treatment of osteopenia and indicates the need for universal handling protocols in caring for this unique population.

Date Presented 4/18/2015 The purpose of this systematic review was to appraise the evidence for the effectiveness of nonnutritional interventions in treating osteopenia of prematurity. The results of a physical activity program with preterm infants are significant, thus affecting occupational therapy intervention in the neonatal intensive care unit (NICU).