An interesting approach for synthesis of disubstituted‐1,2,3‐(NH) triazoles from easily available raw materials and reagents like substituted acetophenones, iodine, DMSO and NaN3 via intermolecular 1,3‐dipolar cycloaddition reaction. Trisubstituted triazoles and its corresponding triazolo pyridazine could be made easily using this method. These are key intermediates for poly benzodithiophene triazole (PBnDT‐TAZ) for solar cells and 1‐benzyl‐1H‐4,5‐dibenzoyl‐1,2,3‐triazole (BDBT) for corrosion inhibition.

No abstract

An efficient synthetic approach for the construction of 3,5‐disubstituted 1,3,4‐thiadiazoles from dithioesters, hydrazine hydrate and triethyl amine has been developed under transition‐metal free condition. This methodology efficiently constructs 3,5‐disubstituted 1,3,4‐thiadiazole in good to excellent yields with the advantages of wide functional group tolerance and operational simplicity.

A vital approach of Fe(OTf)3 and MS3Å (molecular sieves 3Å) mediated one pot synthesis of 1,3-disubstituted imidazo[1,5-a]pyridines from dithioester, 2-methylaminopyridine and alcohol. This methodology involves the intramolecular cyclization and C–C bond formation under mild condition and operates in a single step yielding the products in good to excellent yields. This protocol was compatible to construct various 1,3-disubstituted imidazo[1,5-a] pyridines derivatives.

INTRODUCTION: In the current study, a simple and reliable technique for the synthesis of 2,5-disubstituted 1,3,4-thiadiazoles from ethylbenzimidate and benzothiohydrazides were devised. METHOD: This protocol goes via a base-mediated nucleophilic addition elimination process, followed by intramolecular rearrangement RESULT: Our method utilizes commonly accessible and non-toxic substrates and a simple workup procedure to produce high to exceptional yields (70-91%) of 2,5-diphenyl 1,3,4-thiadiazoles derivatives with a wide range of substitutions. CONCLUSION: we present a simple procedure for the synthesis of 1, 3, 4-thiadiazole using ethylbenzimidate and benzothiohydrazides in the presence of Et3N in DMSO solvent as affordable and easily accessible starting materials to create derivatives under ambient conditions.