Some 12 years ago, a polymorphism of the angiotensin I-converting enzyme (ACE) gene became the first genetic element shown to impact substantially on human physical performance. The renin-angiotensin system (RAS) exists not just as an endocrine regulator, but also within local tissue and cells, where it serves a variety of functions. Functional genetic polymorphic variants have been identified for most components of RAS, of which the best known and studied is a polymorphism of the ACE gene. The ACE insertion/deletion (I/D) polymorphism has been associated with improvements in performance and exercise duration in a variety of populations. The I allele has been consistently demonstrated to be associated with endurance-orientated events, notably, in triathlons. Meanwhile, the D allele is associated with strength- and power-orientated performance, and has been found in significant excess among elite swimmers. Exceptions to these associations do exist, and are discussed. In theory, associations with ACE genotype may be due to functional variants in nearby loci, and/or related genetic polymorphism such as the angiotensin receptor, growth hormone and bradykinin genes. Studies of growth hormone gene variants have not shown significant associations with performance in studies involving both triathletes and military recruits. The angiotensin type-1 receptor has two functional polymorphisms that have not been shown to be associated with performance, although studies of hypoxic ascent have yielded conflicting results. ACE genotype influences bradykinin levels, and a common gene variant in the bradykinin 2 receptor exists. The high kinin activity haplotye has been associated with increased endurance performance at an Olympic level, and similar results of metabolic efficiency have been demonstrated in triathletes. Whilst the ACE genotype is associated with overall performance ability, at a single organ level, the ACE genotype and related polymorphism have significant associations. In cardiac muscle, ACE genotype has associations with left ventricular mass changes in response to stimulus, in both the health and diseased states. The D allele is associated with an exaggerated response to training, and the I allele with the lowest cardiac growth response. In light of the I-allele association with endurance performance, it seems likely that other regulatory mechanisms exist. Similarly in skeletal muscle, the D allele is associated with greater strength gains in response to training, in both healthy individuals and chronic disease states. As in overall performance, those genetic polymorphisms related to the ACE genotype, such as the bradykinin 2 gene, also influence skeletal muscle strength. Finally, the ACE genotype may influence metabolic efficiency, and elite mountaineers have demonstrated an excess of I alleles and I/I genotype frequency in comparison to controls. Interestingly, this was not seen in amateur climbers. Corroboratory evidence exists among high-altitude settlements in both South America and India, where the I allele...

Background: Adequate recovery from exercise is essential to maintain performance throughout training and competition. While compression garments (CG) have been demonstrated to accelerate recovery, the literature is clouded by conflicting results and uncertainty over the optimal conditions of use.Objectives: A meta-analysis was conducted to assess the effects of compression garments on the recovery of strength, power and endurance performance following an initial bout of resistance, running, or non-load bearing endurance (metabolic) exercise.Methods: Change-score data were extracted from 23 peer-reviewed studies on healthy participants. Recovery was quantified by converting into standardized mean effect sizes (ES [± 95% confidence interval ( Conclusion: The largest benefits resulting from CG were for strength recovery from 2-8 h, and > 24 h. Considering exercise modality, compression most effectively enhanced recovery from resistance exercise, particularly at timepoints > 24 h. The use of CG would also be recommended to enhance next-day cycling performance. The benefits of CG in relation to applied pressures and participant training status are unclear and limited by the paucity of reported data. Key Points• Small, significant and very likely benefits on exercise recovery can be achieved through use of compression garments (CG).• The greatest benefits from CG are evident in recovery of strength performance and from resistance exercise, which may imply that CG ameliorate muscle damage.• Next day cycling performance was also subject to large very likely benefits following the use of CG.

We hypothesized that a bout of high or low volume eccentric exercise would protect against muscle damage following a subsequent high volume bout and that adaptation would be attributable to neural changes, independent of the initial exercise volume. Sixteen males performed either 45 (ECC45) or 10 (ECC10) maximal eccentric contractions using the elbow flexors, followed by an ECC45 bout 2 weeks later. Damage markers were measured for the following 96 h; EMG and work done during the first 10 eccentric contractions were also recorded. CK, soreness, and decrements in MVC and range of motion (ROM) were greater in bout 1 than bout 2 (p < 0.01). Soreness, MVC and ROM were greater after the initial ECC45 bout compared to the initial ECC10 bout and the repeated bouts of ECC45 exercise in both groups (p < 0.01). Median frequency decreased from bout 1 to bout 2 (p < 0.001), no differences between groups were observed. An ECC45 bout of maximal eccentric exercise causes more initial damage than an ECC10 bout of maximal eccentric exercise, although both confer protection from subsequent ECC45 bouts of maximal eccentric contractions, which are attributable, at least in part, to a shift in the frequency content of EMG.

BackgroundThere is a necessity for numerous sports to develop strength and aerobic capacity simultaneously, placing a significant demand upon the practice of effective concurrent training methods. Concurrent training requires the athlete to perform both resistance and endurance exercise within a training plan. This training paradigm has been associated with an ‘interference effect’, with attenuated strength adaptation in comparison to that following isolated resistance training. The effectiveness of the training programme rests on the intricacies of manipulating acute training variables, such as exercise sequence. The research, in the most part, does not provide a clarity of message as to whether intra-session exercise sequence has the potential to exacerbate or mitigate the interference effect associated with concurrent training methods.ObjectiveThe aim of the systematic review and meta-analysis was to assess whether intra-session concurrent exercise sequence modifies strength-based outcomes associated with the interference effect.MethodsTen studies were identified from a systematic review of the literature for the outcomes of lower-body dynamic and static strength, lower-body hypertrophy, maximal aerobic capacity and body fat percentage. Each study examined the effect of intra-session exercise sequence on the specified outcomes, across a prolonged (≥5 weeks) concurrent training programme in healthy adults.ResultsAnalysis of pooled data indicated that resistance-endurance exercise sequence had a positive effect for lower-body dynamic strength, in comparison to the alternate sequence (weighted mean difference, 6.91% change; 95% confidence interval 1.96, 11.87 change; p = 0.006), with no effect of exercise sequence for lower-body muscle hypertrophy (weighted mean difference, 1.15% change; 95% confidence interval −1.56, 3.87 change; p = 0.40), lower-body static strength (weighted mean difference, −0.04% change; 95% confidence interval −3.19, 3.11 change; p = 0.98), or the remaining outcomes of maximal aerobic capacity and body fat percentage (p > 0.05).ConclusionThese results indicate that the practice of concurrent training with a resistance followed by an endurance exercise order is beneficial for the outcome of lower-body dynamic strength, while alternating the order of stimuli offers no benefit for training outcomes associated with the interference effect.