Importance: Antibiotics are commonly used to treat and prevent urinary tract infection (UTI), but resistance is growing. Nonantibiotic prophylaxis such as methenamine hippurate (MH) shows clinical promise, but its impact on bladder factors influencing recurrent UTIs (rUTIs) is not well described.Objective: The aim of the study was to examine the effect of MH on bladder inflammation and barrier function in aged mice and women with rUTI.

Natural amenities have always been important to rural America. Places with high natural amenities enjoyed higher levels of employment, population, and income growth. However, the relationship between natural amenities and employment growth varies by industry and natural amenity type. Natural amenities do support the quality of life in rural areas. Yet, their impacts on service and retail sectors are more pronounced, with landscape amenities having greater impacts than weather amenities.

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