Maize is a major crop grown and consumed in Uganda and it requires a high fertilizer input. However, the existing inorganic fertilizers in the market are often not affordable especially to small scale farmers, which results in decreased maize yields in the country. On the other hand, there is an abundance of unutilized animal manure, which, when treated, can be used to increase maize yields. This study evaluated the response of maize to products of different cattle manure treatment methods as well as inorganic fertilizer. The treatments such as cattle manure stored under shade (T), cattle manure stored in the open (M), cattle manure slurry digestate (S), vermicompost (V), and an inorganic fertilizer, DAP (D) were all applied in completely randomized block plots at an equal application rate of 50 kg N ha−1 with four replications per treatment. Control plots (C) where no fertilizer was applied were also considered. The experiment was done for two planting seasons in 2018. Number of leaves, plant height, cob, and grain yields were used to evaluate the performance of different fertilizer treatments. Economic assessment of all the six treatments was also carried out to determine the economic viability of applying these fertilizers on maize. Maize growth parameters and yields were all significantly increased (p < 0.05) with an application of both organic and inorganic fertilizers when compared with the control. However, there was no significant difference (p > 0.05) in the maize yields under the different fertilizer treatments. Vermicomposting was the most economically viable manure treatment method due to low operating costs and higher returns on investment that are supplemented with the production of chicken fodder (earthworm biomass) and, thus, can be recommended to farmers for production of a fertilizer that increases maize yields with assurance of economic returns.