The catalytic asymmetrict otal synthesis of (À)-exiguolide, ac omplex 20-memberedm acrolide embeddedw ith ab is(tetrahydropyran)m otif, is reported. The convergent synthesis involves the construction of the C1-C11t etrahydropyran segment via catalytic asymmetric allylationa nd Prins cyclization, and the formation of the C12-C21p hosphonates egment via catalytica symmetricc yclocondensation reaction and Johnson-Claisen rearrangement. The synthesiso f15-epi-exiguolide is also described.

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