EditorialI studied my PhD in Biomedical Sciences specialized in Neurosciences in the University of Guadalajara, University Center for Health Sciences, earning Honorable Mention in the exam to obtained the degree. As a result of my Doctoral project I got four articles published in various international journals, one of which I am the first author and I have presented results in three posters at different International Congresses. During that period, my studies focused on determining the contribution of chemical neurotransmission systems on high frequency oscillations associated with epileptogenic processes in the laboratory of Neurophysiology and Neurochemistry in University Center of Biological and Agriculture Sciences in University of Guadalajara, where I worked with Dr. Laura Medina-Ceja who was my mentor. In her laboratory we develops electrophysiology techniques for detection of high frequency oscillations, stereotaxic surgery for implanting electrodes and guide cannula, microdialysis and HPLC techniques, on-line measurements of glutamate by fluorescence, and implementation of different experimental models of epilepsy (acute and chronic). We obtained very interesting results on the modulation of neurotransmitter systems in the high-frequency oscillations (250-500 Hz) involved in hippocampal epileptogenesis, especially in temporal lobe epilepsy. Temporal lobe epilepsy (TLE) is the most common type of partial seizures in adults, affecting at least 20% of all patients with epilepsy [1]. The main features of the TLE may be reproduced in chronic models, such a pilocarpine model. We use the model of pilocarpine because mimics the key features of human TLE [2,3]. In this model have been observed high frequency oscillations, called "fast ripples" of 250 to 500 Hz [4]. These fluctuations play an important role in hippocampal epileptogenesis, acting as generators of pathological synaptic changes in specific brain areas. The pathological interictal activity is considered the cause of seizures and neuronal mechanism responsible of TLE in humans and in experimental models [5]. That is the reason why they are interesting in the study of epilepsy, because they are considered as biomarkers of epilepsy. As part of our results published, we conclude that serotonin has an important role in negative modulation of fast ripples. We found that the concentrations of serotonin in rats with spontaneous seizures were decreased compared to normal rats. The decrease of serotonin in rats with spontaneous seizures is closely related to the emergence seizures. Citalopram administration a selective inhibitor of serotonin re-uptake reduces the occurrence of fast ripples and the amplitude [6]. Also we measurement glutamate concentrations by fluorescence on-line and we could detect glutamate in presence of fast ripples, a fact that was not known, and perform the association of fast ripples and glutamate concentrations. We found that the presence of fast ripples not modified glutamate concentrations significantly, but when clusters of fast ripp...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.