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Increased airway responsiveness to acetaldehyde in asthmatic subjects with alcoholinduced bronchoconstriction. M. Fujimura, S. Myou, Y. Kamio, Y. Ishiura, K. Iwasa, T. Hashimoto, T. Matsuda. #ERS Journal Ltd 1999. ABSTRACT: Bronchial responsiveness to acetaldehyde, a main factor in alcoholinduced bronchoconstriction, and methacholine were compared between 10 subjects with alcohol-induced bronchoconstriction and 16 asthmatic subjects without alcohol sensitivity.In the alcohol-sensitive group, the geometric mean (geometric SEM (GSEM)) of the provocative concentration of methacholine (PC20,meth) and acetaldehyde (PC20,acet) causing a 20% fall in forced expiratory volume in one second were 0.947 mg . mL -1 (GSEM 0.139) and 21.0 mg . mL -1 (GSEM 0.112), respectively, which were not significantly different from those in the nonalcohol-sensitive group, which were 0.634 mg . mL -1 (GSEM 0.115) and 31.7 mg . mL -1 (GSEM 0.077), respectively. The ratio of airway responsiveness to acetaldehyde relative to methacholine (log PC20,acet/PC20,meth) was 1.345 0.093 (meanSEM) in the alcohol-sensitive group, which was significantly different from the value of 1.6990.059 in the nonalcohol-sensitive group (p=0.0025). A significant correlation was observed between PC20,meth and PC20,acet in both the alcoholsensitive group (r=0.742, p=0.0115) and nonsensitive group (r=0.882, p<0.0001).In conclusion, the airways of asthmatic subjects with alcohol-induced bronchoconstriction have a selective hyperresponsiveness to acetaldehyde. Eur Respir J 1999; 14: 19±22.

Progressive supranuclear palsy (PSP) is clinically characterized by vertical gaze palsy, postural instability with falls and poor response to dopaminergic drugs. We evaluated the efficacy of repetitive transcranial magnetic stimulation (rTMS) with open-label 5 Hz 5000 pulses for ten days over the supplementary motor area in seven PSP cases. Progressive Supranuclear Palsy Rating Scale (PSPRS) is improved by 7 points compared to the baseline (pre=48, post=41, p<0.05). rTMS might be a therapeutic tool to treat neurological sign of PSP.

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