Introduction Thermoresponsive polymers are a class of smart materials. The properties of such polymers change significantly in a controlled fashion under the influence of external stimuli 1. To develop synthetic polymer systems that act as protein mimics is a great challenge for polymer scientists. The block design of copolymers is an effective strategy for preparing protein mimics using synthetic polymers 2. An alternative way is to control the monomer sequence, which corresponds to the primary structure of proteins 3. However, the interaction among the monomers often makes it difficult to predict the macroscopic properties of the final products 4, 5. In comparison with monomer sequence control, the block design is advantageous for achieving predictable physicochemical properties of the resultant copolymer and scale-up of the preparation process. Because the individual blocks in the copolymer may retain the characteristics of the homopolymer, the numerous reports on the homopolymers may serve as a block library 6 19. Recently, we investigated the solution properties of amphiphilic alternating multiblock AMB copolymers. The