We predicted that people with compassionate goals to support others and not harm them practiced more COVID-19 health behaviors during the SARS-CoV-2 pandemic to protect both themselves and others from infection. Three studies (N = 1,143 American adults) supported these predictions and ruled out several alternative explanations. Compassionate goals unrelated to the health context predicted COVID-19 health behaviors better than the general motivation to be healthy (Studies 2 and 3). In contrast, general health motivation predicted general health behaviors better than did compassionate goals. Compassionate goals and political ideology each explained unique variance in COVID-19 health behaviors (Studies 1–3). Compassionate goals predict unique variance in COVID-19 health behaviors beyond empathic concern, communal orientation, and relational self-construal (Study 3), supporting the unique contribution of compassionate goals to understanding health behaviors. Our results suggest that ecosystem motivation is an important predictor of health behaviors, particularly in the context of a highly contagious disease.