ABSTRACT:The aim of this study was to assess the relationship between glycemic control of type 1 diabetic (DM1) patients and hyposalivation and xerostomia. This observational transversal study used a quantitative approach with a sample of 25 DM1 patients enrolled at the Diabetes Association of Joinville (ADIJO) in 2008. Variables assessed were sialometry through stimulated salivary flow, complaints of xerostomia, and testing for glycemic control: fasting capillary glycemia (FCG) and glycated hemoglobin (HbA1c). The Mann-Whitney U test, chi-square test, and Fisher's exact test were used to verify a possible association among the variables. Most subjects (64%; 16/25) showed concomitant hyposalivation and xerostomia. No significant statistical difference between glycemic control (FCG and HbA1c), hyposalivation, and xerostomia (p=0.54) was found. A high prevalence of hyposalivation and xerostomia was found to be more closely related to higher FCG values at the moment of blood testing than to higher values of HbA1c.

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Objectives: The aim of this study is to evaluate the association between the single nucleotide polymorphism (SNP) rs4284505 within the gene that codifies microRNA17 (miRNA17) and dental fluorosis (DF) in a group of children. Methods: Children living in a city with fluoridation of public water supplies were included. DF was assessed in erupted permanent teeth by Dean's modified index. The miR-SNP rs4284505 was selected in miRNA17 and genotyping was carried out by real-time PCR. Genotype and allelic distributions between DF and control, and between DF phenotypes (mild, moderate and severe) and control were analysed. Results: Among a total of 527 children enrolled for the study, 383 were DF free and 144 presented DF. In the dominant model analysis (AA þ AG vs. GG) the miR-SNP rs4284505 was associated with moderate DF, with carriers of the GG genotype having an increased risk of more than two times for DF (p ¼ 0.031; Odds Ratio ¼ 2.26, Confidence Interval 95%¼ 1.04-4.73). Allelic distribution showed borderline statistical significance for moderate DF with the carriers of G allele having an increased risk for DF (p ¼ .050; Odds Ratio ¼ 1.75, Confidence Interval 95%¼ 1.00-3.12). Conclusion: The miR-SNP rs4284505 in miRNA17 was associated with an increased risk of DF.

Objetivo: Verificar o conhecimento de adolescentes gestantes sobre saúde bucal dos bebês. Materiais e Métodos: Foram entrevistadas 80 adolescentes gestantes (13 -18 anos) que realizaram consultas pré-natais na cidade de Joinville SC, no período de Setembro/2011 até Junho/2012. Os dados obtidos foram analisados para a obtenção dos resultados em forma de estatística descritiva. Aplicou-se o teste do qui-quadrado com significância s p<0,05 para o cruzamento do nível socioeconômico com a transmissibilidade da cárie, momento da erupção dental, inicio da higiene bucal e momento da primeira consulta odontológica do bebê. Resultados: Constatou-se que a idade média das entrevistadas foi 15,5 anos. Dentre elas 47,5% moravam com o pai do bebê; 18,75% eram solteiras e 33,75% casadas, todas de nível socioeconômico baixo, com renda entre 2 a 3 salários mínimos, com média de 4,25 pessoas morando na casa. Quanto ao conhecimento sobre a saúde bucal dos bebês, a maioria desconhecia o que é cárie precoce da infância (96,25%); a sua transmissibilidade (63,75%); o momento da erupção dental do bebê (58,75%). A maioria, 95% das gestantes, pretendia amamentar, e dentre estas, 78,75% deram alguma importância à amamentação. A condição socioeconômica apresentou diferença estatisticamente significante no conhecimento sobre transmissibilidade da cárie, momento ideal para realizar a primeira visita ao dentista e erupção dos dentes. Conclusão: As adolescentes gestantes desconhecem sobre a saúde bucal do bebê indicando necessidade de um programa de saúde bucal na instituição avaliada. Descritores: Gestantes. Adolescente. Saúde bucal.

This study investigated, if genetic variants in BMP2, BMP4 and SMAD6 are associated with variations in the palatal rugae pattern in humans. Dental casts and genomic DNA from 75 patients were evaluated. Each patient was classified as follows: total amount of rugae; bilateral symmetry in the amount, length and shape of the palatal rugae; presence of secondary or fragmentary palatal rugae; presence of unifications; predominant shape; and predominant direction of the palatal rugae. The genetic variants in BMP2 (rs1005464 and rs235768), BMP4 (rs17563) and SMAD6 (rs2119261 and rs3934908) were genotyped. Genotype distribution was compared between palatal rugae patterns using the chi-square test (alpha = 0.05). The allele A was associated with the presence of secondary or fragmentary rugae for rs1005464 (OR = 2.5, 95%CI 1.1–6.3; p = 0.014). Secondary or fragmentary rugae were associated with the G allele in rs17563 (OR = 2.1, 95%CI 1.1–3.9; p = 0.017). rs17563 was also associated with rugae unification (p = 0.017 in the additive model). The predominant shape (wavy) was associated with rs2119261 (p = 0.023 in the additive model). The left–right symmetry of the length of primary rugae was associated with rs3934908 in the recessive model (OR = 3.6, 95%CI 1.2–11.7; p = 0.025). In conclusion, genetic variants in the BMP pathway impacted on palatal rugae pattern.