Sulfur represents one of the most promising cathode materials for next-generation batteries; however, the widely observed polysulfide dissolution/shuttling phenomenon in metal-sulfur redox chemistries has severely restricted their applications. Here it is demonstrated that when pairing the sulfur electrode with the iron metal anode, the inherent insolubility of iron sulfides renders the shuttling-free nature of the Fe-S electrochemical reactions. Consequently, the sulfur electrode exhibits promising performance for Fe 2+ storage, where a high capacity of ~1050 mAh g -1 , low polarization of ~0.16 V as well as stable cycling of 150 cycles have been realized. The Fe-S redox mechanism was further revealed as an intriguing stepwise conversion of S 8 ↔ FeS 2 ↔ Fe 3 S 4 ↔ FeS, where a low volume expansion of ~32.6% and all-solid-state phase transitions facilitate the reaction reversibility. This study suggests an alternative direction to exploit sulfur electrodes in rechargeable transition metalsulfur batteries.The pressing need for renewable energy storage entails the development of cost-effective and sustainable battery technologies. [1] Along this line, batteries that employ earth-abundant elements such Recently, our group investigated a Fe-metal battery, where a Prussian blue cathode undertakes reversible Fe 2+ (de)insertion reactions. [38] In this work, we further demonstrate Fe-S battery chemistry Received: ((will be filled in by the editorial staff))Revised: ((will be filled in by the editorial staff))

Anion storage in cathode of dual-ion batteries provides leeway for new battery chemistries. For high energy density and better safety, it is desirable but challenging to reversibly intercalate chloride in a graphite cathode because either the oxygen or chlorine evolution reaction can prevail over chloride insertion. The primary barrier is the lack of suitable aqueous electrolytes that suppress these parasitic reactions. Herein, we report an aqueous deep eutectic solvent gel electrolyte that allows reversible chloride storage for graphite based on a chloride-based electrolyte via the formation of iodine–chloride interhalogens. The results suggest three reversible steps: iodine plating on the host surface, oxidation to form I-Cl interhalides, and then intercalation into graphite. As a result, the graphite cathode delivers a high reversible capacity of 291 mAh g–1 with stable cycling performance. Facilitated by the same mechanism, a porous graphenic carbon delivered a record-high capacity of over 1100 mAh g–1.

Abstract.A 34-KD protein encoded by the SEI-1 gene (p34 ), is a relatively recently discovered oncoprotein that has multiple important biological functions. Our data show that p34 SEI-1 enhances cancer cell survival and promotes tumorigenesis by downregulating the tumor suppressor PTEN, a negative regulator of the PI3K/AKT signaling pathway, and therefore activating the PI3K/AKT signaling pathway. In this process, p34 SEI-1 positively affects NEDD4-1 gene expression both at the transcriptional and protein levels. Furthermore, the expression levels of p34 SEI-1 and NEDD4-1 were found to be coordinated in tumor tissues obtained from patients with breast cancer. We also show that p34 SEI-1 affects the subcellular localization of PTEN.

Aqueous dual‐ion batteries (DIBs) are promising for large‐scale energy storage due to low cost and inherent safety. However, DIBs are limited by low capacity and poor cycling of cathode materials and the challenge of electrolyte decomposition. In this study, a new cathode material of nitrogen‐doped microcrystalline graphene‐like carbon is investigated in a water‐in‐salt electrolyte of 30 m ZnCl2, where this carbon cathode stores anions reversibly via both electrical double layer adsorption and ion insertion. The (de)insertion of anions in carbon lattice delivers a high‐potential plateau at 1.85 V versus Zn2+/Zn, contributing nearly 1/3 of the capacity of 134 mAh g−1 and half of the stored energy. This study shows that both the unique carbon structure and concentrated ZnCl2 electrolyte play critical roles in allowing anion storage in carbon cathode for this aqueous DIB.

TRIP-Br1 oncogenic protein has been shown to have multiple biological functions in cells. In this study, we demonstrate that TRIP-Br1 functions as an oncoprotein by inhibiting autophagy, apoptosis, and necroptosis of cancer cells and eventually helping them to survive under the nutrient/serum starved condition. TRIP-Br1 expression level was significantly increased in conditions with low levels of nutrients. Nutrient depleted conditions were induced by culturing cancer cells until they were overcrowded with high cell density or in media deprived of glucose, amino acids, or serum. Among them, serum starvation significantly enhanced the expression of TRIP-Br1 only in all tested breast cancer cell lines (MCF7, MDA-MB-231, T47D, MDA-MB-435, Hs578D, BT549, and MDA-MB-435) but not in the three normal cell lines (MCF10A, HfCH8, and NIH3T3). As compared with the control cells, the introduction of TRIP-Br1 silencing siRNA into MCF7 and MDA-MB-231 cells accelerated cell death by inducing apoptosis and necroptosis. In this process, TRIP-Br1 confers resistance to serum starvation-induced cell deaths by stabilizing the XIAP protein and inhibiting cellular ROS production. Moreover, our data also show that the intracellular increase of TRIP-Br1 protein resulting from serum starvation seems to occur in part through the blockage of PI3K/AKT signaling pathway.