Background-Completeness of cytoreduction is an independent prognostic factor following cureintended surgery for peritoneal carcinomatosis (PC). Intraoperative detection of the minimal residual disease may aid in achieving complete cytoreduction. NV1066, a genetically-engineered herpes simplex virus carrying the transgene for green fluorescent protein (GFP), selectively infects cancer cells. NV1066-infected cancer cells express GFP that can be detected by fluorescence laparoscopy. We sought to determine the feasibility of Virally-directed Fluorescent Imaging (VFI) in the intraoperative detection of minimal residual disease following cytoreductive surgery.

PurposeEndoscopic submucosal dissection (ESD) in early gastric cancer causes an artificial gastric ulcer and local inflammation that has a negative intraprocedural impact on additional laparoscopic gastrectomy in patients with noncurative ESD. In this study, we analyzed the effect of ESD on short-term surgical outcomes and evaluated the risk factors.Materials and MethodsFrom January 2003 to January 2013, 1,704 patients of the National Cancer Center underwent laparoscopic gastrectomy with lymph node dissection because of preoperative stage Ia or Ib gastric cancer. They were divided into 2 groups: (1) with preoperative ESD or (2) without preoperative ESD. Clinicopathologic factors and short-term surgical outcomes were retrospectively evaluated along with risk factors such as preoperative ESD.ResultsSeveral characteristics differed between patients who underwent ESD-surgery (n=199) or surgery alone (n=1,505). The mean interval from the ESD procedure to the operation was 43.03 days. Estimated blood loss, open conversion rate, mean operation time, and length of hospital stay were not different between the 2 groups. Postoperative complications occurred in 23 patients (11.56%) in the ESD-surgery group and in 189 patients (12.56%) in the surgery-only group, and 3 deaths occurred among patients with complications (1 patient [ESD-surgery group] vs. 2 patients [surgery-only group]; P=0.688). A history of ESD was not significantly associated with postoperative complications (P=0.688). Multivariate analysis showed that male sex (P=0.008) and laparoscopic total or proximal gastrectomy (P=0.000) were independently associated with postoperative complications.ConclusionsESD did not affect short-term surgical outcomes during and after an additional laparoscopic gastrectomy.

No abstract

No abstract