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Recent improvements in weather observation and monitoring have increased the precision of tornado warnings. The National Weather Service currently issues storm-based tornado warnings, and even more geographically specific warnings that include probability information are under development. At the same time, the widespread proliferation of smartphone and mobile computing technology supports the rapid dissemination of graphical weather warning information. Some broadcasters and private companies have already begun using probabilistic-style tornado warning graphics. However, the development of these new types of warnings has occurred with limited research on how users interpret probabilistic visualizations. This study begins filling this void by examining responses to color scheme and relative position using probabilistic tornado warning designs. A survey of university students is used to measure the level of perceived fear and likelihood of protective action for a series of hypothetical warning scenarios. Central research questions investigate 1) differences in responses across warning designs, 2) clustering of extreme responses in each design, 3) trends in responses with respect to probability levels, 4) differences in responses inside versus outside the warnings, and 5) differences in responses near the edges of the warning designs. Results suggest a variety of trade-offs in viewer responses to tornado warnings based on visual design choices. These findings underscore the need for more comprehensive research on visualizations in weather hazard communication that can aid meteorologists in effectively warning the public and spur appropriate tornado protection behaviors in a timely manner.

Flavonoids isolated from citrus were evaluated for their ability to affect the inflammation response through suppression of cytokine expression by human monocytes. Several polymethoxylated flavones inhibited lipopolysaccharide-induced monocyte expression of tumor necrosis factor (TNFalpha). Subsequent studies centered on the compound 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) which produced the highest inhibition (IC50 = 5 microM). HMF was also a potent inhibitor of macrophage inflammatory protein-1alpha (MIP-1alpha) and interleukin-10 (IL-10) production, but not of IL-1beta, IL-6, or IL-8 production. Suppression of TNFalpha production was at the level of mRNA induction as determined by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). HMF was also a potent inhibitor of human phosphodiesterase activity and was shown to induce a substantial elevation of cAMP levels in monocytes. The similarity of these results to the inhibition profile of the known phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine, suggests that the polymethoxylated flavones inhibit cytokine production in part by suppression of phosphodiesterase activity. The ability of HMF to also inhibit IL-10 production suggests the additional existence of a phosphodiesterase-independent mechanism for this compound.