Objectives We evaluated MYC and p53 expression, TP53 aberration, their relationship, and their impact on overall survival (OS) in acute lymphoblastic leukemia (ALL)/lymphoblastic lymphoma (LBL). Methods We identified 173 patients with ALL and LBL, including 12 cases of mixed-phenotype acute leukemia, 8 cases of therapy-related B-cell ALL (B-ALL), 119 cases of B-ALL, and 34 cases of T-cell ALL/LBL diagnosed from 2003 to 2019. We retrospectively assessed p53 and MYC expression by immunohistochemistry of bone marrow and correlated MYC expression with p53 expression and TP53 aberration. Results Expression of p53 and MYC was present in 11.5% and 27.7% of ALL/LBL cases (n = 20 and n = 48), respectively. MYC expression was significantly correlated with p53 expression and TP53 aberration (P = .002 and P = .03), and p53 expression and MYC expression had an adverse impact on OS in patients with ALL/LBL (P < .05). MYC and p53 dual expression as well as combined MYC expression and TP53 aberration had a negative impact on OS in patients with ALL/LBL. Conclusions MYC expression is correlated with p53 overexpression, TP53 aberration, and poor OS in patients with ALL/LBL.

from a larger prevalence and proportion of women among surgical trainees in all disciplines (Fig 1A). However, growth rate among female urology residents (28%) lagged behind most specialties, ranking second-to-last (range 9%-149%, all p <0.01). While the proportional change in urology applicants has been significant (33%, p <0.01), growth rates have markedly slowed in the past 5 years compared to women in practice and training since 2007 (Fig 1B).CONCLUSIONS: While female representation in urology has improved relative to other surgical disciplines, slowing rates of recruitment among female residency applicants suggest a longer trajectory toward gender parity.