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Objective The purpose of this study was to assess the rate of lymph node (LN) metastasis in comprehensively staged ovarian clear cell carcinoma (OCCC) clinically confined to the ovary and determine factors associated with LN metastasis. Methods We identified all cases of OCCC treated at four institutions from January 1994 through December 2011. We included cases with disease grossly confined to the ovary that had surgical staging performed, including at least 10 LNs sampled. Clinical and pathologic data were abstracted from electronic medical records and a de-identified data set was compiled and processed at a single institution. Factors potentially associated with LN metastasis were tested. Appropriate statistical tests were performed. Results We identified 145 eligible cases that met the criteria for this analysis. Median age was 52.9 years (range, 30–81), and median total LN count was 19 (range, 10–74). Seven (4.8%) of 145 comprehensively staged cases had LN metastasis; 6 of these cases (4.1%) were isolated metastasis. Cytologic washings, peritoneal, omental and fallopian tube involvement were not associated with nodal metastasis. Cases with ovarian surface involvement and positive cytology had a 37.5% incidence of LN positivity, which was statistically meaningful when compared with all other cases (p=0.003). Conclusion Women who underwent comprehensive staging for clinical stage I OCCC had a LN metastasis rate of 4.8%. The subgroup of cases with both ovarian surface involvement and positive cytology had the highest incidence of LN metastasis. This may influence clinical decision making on whether to perform lymphadenectomy in patients with incidental OCCC found after salpingo-oophorectomy.

RBT is independently associated with significantly lower postoperative pain and pain medication requirements compared to LSC. The amount of intraoperative fentanyl analgesia does not appear to correlate with postoperative pain.Endometrial cancer is the most common gynecologic malignancy in the United States, with an estimated 47,130 new cases in 2012.1 An estimated 287,100 women were diagnosed with endometrial cancer worldwide in 2008.2 Surgery is the primary treatment of choice for the majority of these women.3 The standard surgical approach has been total abdominal hysterectomy, bilateral salpingo-oophorectomy, and staging via laparotomy. Multiple retrospective series have shown that a less invasive surgical approach via laparoscopy (LSC) is feasible and safe, and also associated with improved perioperative outcomes compared to laparotomy in these patients.4 The Gynecologic Oncology Group (GOG) published results of the largest randomized trial (LAP2) comparing LSC to laparotomy in patients with newly diagnosed endometrial carcinoma in 2009.5,6 This landmark study essentially changed the accepted standard surgical approach in this group. Postoperative complications, median blood loss, and median length of stay (LOS), despite increased operative time, were significantly lower in LSC patients despite 25 % requiring conversion to laparotomy.5 The first 802 eligible patients randomized in LAP2 also participated in a quality-of-life (QOL) study. Within 6 weeks of surgery, patients assigned to LSC reported significantly better QOL on all scales other than fear of recurrence.6 Overall, during this 6-week postoperative period, patients assigned to LSC had superior QOL, fewer physical symptoms, less pain and pain-related interference with functioning, better physical functioning and emotional state, earlier resumption of normal activities, earlier return to work, and better body image compared to those assigned to laparotomy.6 Recurrence-free and overall survivals were the same in both groups.7 Multiple published retrospective series have shown possible benefits, such as reduced postoperative pain, using the robotic (RBT) platform compared to LSC or laparotomy in patients with endometrial cancer.8-11 In a randomized trial, LSC was found to be associated with less postoperative pain compared to vaginal approaches in patients undergoing hysterectomy for benign gynecologic disease.12 A small retrospective series reported further reductions in postoperative pain in patients who had undergone an RBT hysterectomy compared to a standard total LSC hysterectomy for benign indications.13 A recent cost analysis suggested that patients experienced less pain and required less pain medication use after RBT procedures compared to LSC for endometrial cancer.14 Based on these reports, we sought to analyze postoperative pain and the use of pain medication in patients undergoing RBT compared to standard transperitoneal LSC procedures for newly diagnosed endometrial cancer during a concurrent time period. Of note, current RBT surgery is not...

Objectives: Urine is the most common material tested in clinical microbiology laboratories. Automated analysis is already performed, permitting quicker results and decreasing the laboratory technologist's (LT) workload. These automatic systems have introduced digital imaging concepts. PhenoMATRIX (PHM) is an artificial intelligence software that merges picture algorithms and user rules to provide presumptive results. This study aimed at designing a tailored workflow using PHM, performing its validation and checking its performance in routine practice. Methods: Two data collections including 96 and 135 urine samples from nephrostomy/ureterostomy and artificial bladder (US), 948 and 1257 urine samples from catheter (UC) and 3251 and 2027 midstream urine (MSU) were used to compare LT results with those obtained using two versions of PHM. Another 19 US, 102 UC and 508 MSU were used to monitor performance level 3 months after routine implementation. Results: Before and after revisions, agreement between the first version of PHM and LT results were 83% (95% confidence interval [CI], 74.3e90.2) and 83% (95% CI, 75.3e90.9) (US), 66.7% (95% CI, 63.5e69.5) and 71.7% (95% CI, 68.8e74.4) (UC) and 65.4% (95% CI, 63.8e67.1) and 76% (95% CI, 74.1e77.1) (MSU). The second version improved results, demonstrating 96.2% (95% CI, 91.6e98.8) and 97% (95% CI, 92.6e99.2) (US), 87.5% (95% CI, 85.5e89.2) and 88.9% (95% CI, 87.0e90.5) (UC) and 91% (95% CI, 89.7e92.1) and 92% (95% CI, 91.1e93.4) (MSU) of agreement with LT results before and after revisions. The reliability of PHM results was confirmed by a routine study demonstrating 92% (95% CI, 90.0e94.2) overall agreement. Conclusions: PHM showed high performance, with >90% of results in agreement with LT. PHM could help standardize and secure results, prioritize positive plates during analytical workflow and likely save LT time.

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