Chronic fatigue syndrome (CFS) is an illness characterized by persistent and relapsing fatigue, often accompanied by numerous symptoms involving various body systems. The etiology of CFS remains unclear. Despite considerable worldwide efforts, no single etiology has been identified to explain the development of chronic fatigue syndrome (CFS). It is likely that multiple factors promote its development, sometimes with the same factors both causing and being caused by the syndrome. However, a number of recent studies have shown oxidative stress may be involved in its pathogenesis. Any dysfunction in the Mitochondria, the key organelle responsible for cellular energy production can result in the excess fatigue and other symptoms that are common complaints in almost every chronic disease. Several components of this system require routine replacement, and this need can be facilitated with natural supplements. A detailed review of the literature suggests a number of marginal nutritional deficiencies may have etiologic relevance. In this review article an attempt has been made to look into these factors in relation to chronic fatigue syndrome.

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