The application of HOTS for students is very urgent, considering the times with extraordinary challenges. The application of 21st century learning skills to improve students' HOTS requires the involvement of all parties in the educational environment, and not only at the concept level, but also in the form of real practice. This study aims to determine the students' HOTS ability in stoichiometry learning through the PjBL model in terms of chemical literacy abilities. This research is a quasi-experimental study using a 2x2 factorial design. The results of the research showed that there were differences in the HOTS abilities of students who were given the PjBL model compared to the direct learning model, there were differences in students' HOTS abilities in terms of students' chemical literacy abilities and there was no interaction between the learning model and students' chemical literacy skills on students' HOTS abilities.