In this paper, heterocyclic hexagonal rings were prepared for pyrimidine derivatives [I9-I16] by reacting a mole of gluconate derivatives with a mole of cyanoguanidine and using ethanol as a solvent. The accuracy of the compositions of the prepared compounds was confirmed by measuring the physical properties, including melting point, color, and molecular weight, as well as through spectroscopic measurements, including the infrared spectrum, the proton nuclear magnetic resonance spectrum, and the carbon-13 nuclear resonance spectrum. The biological activity of some prepared compounds and on two types of pathogenic bacteria, one of which is Gram-positive, which is Staphylococcus aureus, and one of which is Gram-negative, which is Escherichia coli, was studied. And the culture medium of the Multer Hinton Agar type was used, and chemical solutions were prepared for the two compounds (I9, I16) with concentrations (0,01, 0.001, 0.0001) mg /ml using a solvent dimethyl sulfoxide (DMSO). The sensitivity test of bacterial isolates used in the study was carried out by diffusion method, and the antibiotic Ciprofloxacin was used as a control sample. The effect of compound I15 on the removal of free radicals was also studied using DPPH root and at different concentrations.

In this paper, heterocyclic hexagonal rings were prepared for pyrimidine derivatives [I9-I16] by reacting a mole of gluconate derivatives with a mole of cyanoguanidine and using ethanol as a solvent. The accuracy of the compositions of the prepared compounds was confirmed by measuring the physical properties, including melting point, color, and molecular weight, as well as through spectroscopic measurements, including the infrared spectrum, the proton nuclear magnetic resonance spectrum, and the carbon-13 nuclear resonance spectrum. The biological activity of some prepared compounds and on two types of pathogenic bacteria, one of which is Gram-positive, which is Staphylococcus aureus, and one of which is Gram-negative, which is Escherichia coli, was studied. And the culture medium of the Multer Hinton Agar type was used, and chemical solutions were prepared for the two compounds (I9, I16) with concentrations (0,01, 0.001, 0.0001) mg /ml using a solvent dimethyl sulfoxide (DMSO). The sensitivity test of bacterial isolates used in the study was carried out by diffusion method, and the antibiotic Ciprofloxacin was used as a control sample. The effect of compound I15 on the removal of free radicals was also studied using DPPH root and at different concentrations.

Using ethanol as a solvent, heterocyclic hexagonal rings for 2-amino-pyran derivatives (I33-I40) were produced by reacting a mole of chalcones derivatives with a mole of malononitrile. Physical properties such as melting point, colour, and molecular weight and spectroscopic measurements such as the infrared spectrum, [1H-NMR], [13C-NMR] spectrum were used to confirm the accuracy of the prepared compounds' compositions. The biological activity of various produced compounds was investigated in two species of pathogenic bacteria, one of which is Gram-positive, Staphylococcus aureus, and the other, Gram-negative, Escherichia coli. Chemical solutions for the two substances (I25, I32) with concentrations (0,01, 0.001, 0.0001) mg /ml were created using a solvent DMSO and Multer Hinton Agar growth medium. The antibiotic Ciprofloxacin was utilized as a control sample for the diffusion sensitivity test of the bacterial isolates used in the investigation. Using DPPH root and varied concentrations, the impact of chemical (I32) on the elimination of free radicals was also investigated. Breast cancer cells were taken from Baghdad's Medical City and used to test the efficiency of several produced chemicals against them.