The physical, chemical, or biological aspects of a water sample will generally comply with water quality guidelines or requirements to assess the consistency of the water for human use. Drinking water has been assessed monthly over the year 2019 for 6 vicinities in Dishna city such as Naga-Talha, Azaziyah, Safaruh, Alkhawla, Alsaeayida, and Nag-Abo-Elhamed. These places account for 50% of the drinking water supplying Dishna city. Aluminum content in all districts has crisis (5-17%) where they have surpassed Qena Water Pollution Control Regulations on Drinking Water Quality and (30-140%) of WHO (World Health Organization). Conductivity also exceeded WHO limits by 3-4% in all districts during autumn except Alsaeayida district.Microbiological parameters in some districts were also out of acceptable limits such as fecal coli and fecal streptococci in Naga talha and Naga aboelhamed respectively; total coli, fecal coli, and fecal streptococci in Azaziyaha. CCA (Canonical Corresponding Analysis) indicates that total algal count and microbial content were in positive correlation with all or some physicochemical parameters. Although almost all parameters examined for the Dishna drinking water samples were within the limits of the guidelines on drinking water quality of the World Health Organization and the Qena authorities› Water Pollution Control Regulation. However, some treatment processing should be concerned with some disturbing parameters. Seasonal water quality monitoring is also seen as a good practice for evaluating plants and processes for water treatment.