We present a case of a 78-year-old female patient who was admitted to the medical intensive care unit because of high fever, weakness and abdominal pain. Bacteriological studies showed sepsis and allowed the isolation of Actinomyces odontolyticus and Abiotrophia species as causative agents. Further investigation led to a diagnosis of liver abscess from which there was also isolated Haemophilus parainfluenzae, Streptococcus intermedius and Streptococcus anginosus, as well as the above mentioned bacteria. All named microorganisms represent a part of normal oropharyngeal flora and may cause abscesses or sepsis under certain circumstances. As far as we know, liver abscess due to Abiotrophia species was never reported.