Background: Objectives include evaluation of compliance of asthmatic children and their mothers through assessment of mother's knowledge, attitude, practices and behavior regarding bronchial asthma and its management at Pediatric Outpatient Clinic at Zagazig University Hospitals. Methods: A crosssectional study was conducted during the period from April 2018 to January 2019 at Pediatric Outpatient Clinic at Zagazig university Hospitals. The study included 137 mothers of asthmatic children. Data were collected by detailed History, full examination, PFTs (Pulmonary function tests) and a structured interview questionnaire included: demographic data of the mothers and their asthmatic children, Assessment of asthma triggers, Asthma Knowledge Questionnaire, Modified Asthma Self-Management Questionnaire, and Morisky Medication Adherence Scale. Results: stress, cold illness, pesticides, air pollution, sports, clutter, and Gasoline were the most common asthma triggers in the present study. Only 37.2% of the studied mothers had adequate knowledge about asthma. Rural residents, mothers with high education and working mother had significantly more adequate knowledge about asthma. Compliance among the studied mothers was not satisfactory as only 32.1% of them had adequate compliance. Urban residents, mothers with secondary education and housewives had significantly more adequate compliance. Mothers of children with moderate to severe asthma had significantly higher compliance level. Less absenteeism was associated with adequate compliance of mothers. There was a statistical significant positive correlation between children compliance score and disease duration. There were statistical significant negative correlations between total knowledge and Selfmanagement scores. Conclusion: In the present study, there were lack of asthma self-management ,knowledge and compliance. stress, cold illness, pesticides, air pollution, sports, clutter ,and Gasoline were the most common asthma triggers in the present study.