Angioedema is a local, non-inflammatory, self-limiting oedema that is circumscribed, and is caused by increased vascular permeability and leakage of plasma into the deeper skin layers. Angioedema can occur with or without urticaria. It can be acute or chronic (more than six weeks in duration) as well as being allergic, hereditary or idiopathic in nature. The reaction is self-limited, usually lasting few days, but may occur repetitively with each exposure to the allergen which may cause a fatal reaction at some point. This is the main reason behind the removal of the valuable drug (rivaroxaban) like in our patient because the result of angioedema occurred 2 months after administration of the rivaroxaban.