Objective: Comparative analysis of the results of the visual evoked potential investigation according to stages of optic neuritis (ON).Material and Methods: The study included 90 patients (90 eyes) with different stages of ON. A control group comprised 10 somatically healthy persons (10 eyes) of the same age without ophthalmic pathology. All examined underwent standard ophthalmologic examination, including visometry, tonometry, perimetry, and ophthalmoscopy, as well as optical coherence tomography (OCT) and visual evoked potentials (VEP) determination.Results: The VEP parameters provide identification of the functional disorders of the optic nerve. Our results showed that there is delayed latency and reduced amplitude of the P100 component in patients with ischemic and atrophic stages of the disease. In ON, P100 was the most informative index. We noted that the N145 parameter in ON is not very informative.

Inflammatory complications of the organ of vision in the time of COVID-19 can be manifested as conjunctivitis, scleritis, episcleritis, keratitis, uveitis and optic neuritis. It is essential to collect anamnesis, examine the blood for the presence of COVID 19 and treat these patients with the help of infectious disease specialists. Correct diagnosis of inflammatory ocular complications in the presence of COVID 19 makes it possible to prevent ocular complications, such as: ulcers and corneal penetration; fusion and overgrowth of the pupil,which leadto secondary glaucoma; endoophthalmitis, panophthalmitis and optic nerve atrophy. Timely intensive medical care and adequate treatment of these complications lead to a decrease in disability in this category of patients.Keywords:Ophthalmology, COVID-19,complications, ulcers, endoophthalmitis, panophthalmitis, gastrointestinal tract, cavernous sinus thrombosis

The purpose of this study was to identify the nature and dynamics of morphological changes in the anterior segment of the rat eye (ASE) in the aspect of regeneration opportunities under an experimental alkali burn (EAB) in the fast and slow acetylators. Materials and Methods:The experiment was performed on 50 adult outbred male Wistar rats weighting from 180 to 200g. According to results of testing, all animals were divided into 2 groups: fast acetylators and slow acetylators. The experimental chemical eye burn model was performed according to standard procedures by applying a 10% NaOH solution for 10 seconds. The tissues of ASE were the object of this study. The morphological examination was performed on the 3rd, 5th, 12th, and 30th day after EAB.Results: The morphological changes of eye tissues after EAB are formed immediately after the injury involving the deep tissues and are characterized by severe manifestations of the colliquative burn of all eye structures. The intensity of the pathological process increases over time with subsequent reduction of pathological changes on day 30 post-injury. The intensity of morphological changes and their dynamics vary depending on the N-acetylation, given equal external conditions. Regarding the features of drug biotransformation in slow acetylators, it is advisable to take acetylation phenotype into account when choosing the treatment method. (Int J Biomed. 2015;5(4):219-223.)