In this paper, channel overhead is reduced by exploiting channel sparsity for multiple input multiple output-orthogonal frequency division multiplexing (MIMO-OFDM) system. Where, compressive sensing (CS) based dictionary design algorithms has been adopted as a channel estimation technique in high mobile systems with minimal number of pilots, such as high-speed train (HST) systems. A novel framework design of the dictionary-based CS was proposed considering both delay and Doppler effects in order to correctly recover the channel response. The channel under consideration is a 2 by 2 space-time block code (STBC) MIMO channel. Simulation tests according to the international telecommunication union (ITU) channel model demonstrated the suitability of the proposed dictionary for estimating the channel impulse response (CIR) of a liner time varying (LTV) channel with a mobility approaches 675 Km/h related to a Doppler frequency of 1500 Hz and 2.4 GHz carrier frequency. Two CS recovery algorithms were applied; orthogonal matching pursuit (OMP) and basis pursuit (BP), where by about 7 dB gain in signal to noise ratio (SNR) was achieved with mobility of 675 Km/h using OMP as compared to BP at a bit error rate (BER) of 10 −3 with 128 OFDM subcarriers.