EGFR particularly stimulates downstream targets of the pro-oncoproteins family such as RAS-RAF-MEK-ERK and AKT-PI3K-mTOR signaling pathways (ZHANG and LIU, 2002). In cancer cells, the overexpression of EGFR, and the mutant downstream effectors such as KRAS, BRAF, PIK3CA, P53 and PTEN have been linked to a dynamic change that occurs in cancer cells leading to drug resistance, distinct oncogenicity alteration,
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