Background: Intrauterine growth restriction [IUGR] represented a challenging health problem, faced during daily clinical practice. Early diagnosis is of crucial importance. Aim of the work: To determine the value of the aortic isthmic flow index and the left mod-myocardial performance index [MPI] in the prediction of adverse perinatal outcomes in fetuses affected by IUGR. Patients and Methods: Forty Singleton fetuses with IUGR between 28 and 34 weeks were recruited. The left mod-MPI and the isthmic flow index [IFI] were calculated. Ultrasound indices had been correlated with perinatal outcome. Results: There was a statistically significant association between abnormal aortic isthmus diastolic flow and low 1-minute Apgar score and neonatal intensive care unit [NICU] admission. There was a statistically significant association between the left mod-MPI and the meconium stained amniotic fluid [AF], the need for Neonatal resuscitation, NICU admission, neonatal sepsis, and neonatal death. When considering cutoff value for prediction of adverse fetal outcome by Left MPI, a cutoff of 0.53 confers 85.2% sensitivity, 80% specificity, PPV 92%, NPV 66.7%, and accuracy of 83.8%. In addition, 85% of fetuses had normal Aortic isthmus [AoI] waveform [IFI type I] and 15% had abnormal AoI waveform, and there was a statistically significant association between abnormal AoI diastolic flow and each of [IFI of II, III, V], [low 1-minute Apgar score] and [NICU admission]. Conclusion: AoI IFI and left mod-MPI could be considered valuable for the assessment of chronic placental insufficiency, and play a role in prediction of adverse perinatal outcome associated with IUGR.

Background: Infertility means a couple in their reproductive age not bearing a child after a year's unprotected intercourse. It has a global prevalence of 12% to 15%. Aim of the work: The aim of this study is to evaluate the combined effect of several lifestyle behaviors [Exercise, smoking, alcohol, dietary habits and stress] on assisted reproductive techniques [ART] outcomes. Patients and Methods: This study included 700 patients undergoing intracytoplasmic sperm injection. Patients answered a questionnaire [simple life style questionnaire; SLIQ] and analysis examined the relationship between lifestyle with the intracytoplasmic sperm injection cycles outcomes. Comparison of SLIQ scores as measured by the scoring template with scores obtained by the health professionals' blinded assessment of the questions validated our scoring scheme. We achieved a correlation coefficient of 0.77 [P<0.001] between SLIQ scores and blinded reviewers' scores. Results: The mean number of oocytes was 6.31±5.5; and [73%] of oocytes were of good quality; the mean number of embryos was 3.22±3.36 and 69.0% were of good quality. Finally, 399 patients [57%] get pregnant. There was significant relation between life style behaviors and results of ART. There was Positive correlation between [total score and each of quality of oocytes, quality of embryos and pregnancy test. Conclusion: This study has highlighted that lifestyle behaviors can adversely affect general health and reproductive performance.