Total infusion time: 324 min Volume of each solution administered: solution A,21.25 mL;solution B, 42.25 mL; and solution C, 516.67 mL. Solutions were prepared in the cytotoxicity unit of the pharmacy department. The tubing of each bag is primed with the antineoplastic drug in the pharmacy and connected to a running saline line in close proximity to the patient, thus enabling delivery of small volumes during the initial steps of the desensitization protocol. The protocol was adapted from Castells et al [4]. Irinotecan is always diluted in 500 mL in our hospital, instead of 250 mL, as per the original protocol, and the infusion rate is adapted to that change. No diluent is removed when a solution is prepared owing to our local safety requirements: the amounts added are 0.