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This is the first report and investigation of a patch antenna in optical frequency range. Variety of plasmonic nanoantenna reported so far is good at enhancing the local field intensity of light by orders of magnitude. However, their far-field radiation efficiency is very poor. The proposed patch antenna emits a directional beam with high efficacy in addition to enhancing the intensity of near field. The nano-patch antenna (NPA) consists of a square patch of gold film of dimension 480 nm 2 , placed on a substrate of dielectric constant e r = 3.9 and thickness 150 nm with a ground plane of gold film of dimension 1,080 nm 2 . The NPA resonates at 210 THz and has gain nearly 2 dB and radiation efficiency 45.18 %. The NPA might be useful in variety of applications such as optical communication, nano-photonics, biosensing, and spectroscopy.

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Objective Calcium is fundamental component of bone tissue. It is present in extracellular fluid in ionized form, some are bounded with albumin while a few are of the complex anionic form. Calcium regulates many biochemical processes. Loss of calcium causes hypocalcemia further lead to osteopenia and osteoporosis. Proton pump inhibitor causes mal-absorption of calcium that leads to poor bone metabolism might causes hip fracture. Some studies via microRNA gene regulatory networks have been analyzed in the present study. Methods Microarray gene expression dataset has been retrieved by using NCBI gene expression Omnibus (GEO) database. Benjomini and Hochberg algorithm was used for identifying DEG’s and pre-processing of datasets. Heatmap plot and principal component analysis plot were generated by using online tool ClustVis for DEG’s. PPI network and sub network were analyzed by finding functional interactions among protein via online tool STRING v 10.5. DEG’s functional pathways analysis has been done by using DAVID (Database for Annotation, Visualization and Integration Discovery) software. Results A number of 3390 differentially expressed genes (DEG’s) were identified. …..were up-regulated and were down-regulated genes. DEGs related to Hypocalcemia and Bone signaling were 53, osteogenesis and bone signaling both were 86, whereas, 8 DEG’s related to hypocalcemia, Osteogenesis, and Bone signaling. The network of protein-protein interaction and sub network was having ITCH, CKAP4(Up) and FBXW11, RAB37(down) DEGs were concerned in hypocalcemia and were forming hub nodes while CHML, ATP11A, TMEM30A (Up) and YWHAE, AP1M1, FYN(down) DEG’s forming were all related to bone signaling. Functional enrichment analysis was performed notably enriched major molecular functions, biological processes and cellular components of novel DEG’s (FDR<0.05) related to hypocalcemia and osteoporosis were found. Conclusion Thus by concluding the genes ie; ITCH, CKAP4, FBXW11, RAB37, CHML, ATP11A, TMEM30A, YWHAE, AP1M1, FYN, CTNNB1, UBE2D1, RAP1A, EGFR, MAPK1 and AKT1, whether are unregulated or downregulatd in the diseased tissue samples, and plays a essential role in disease progression. These hub genes are occupied in different biological, molecular and cellular functions which might be related to bone signaling or osteoporosis. For the further cross validation wet lab experiments are required to validate gene roles.

Background: Preterm delivery is major cause of perinatal morbidity and mortality. Measuring cervical length (CL) with ultrasonography has become increasingly acceptable as an early diagnostic procedure in patients at risk for PTL, with transvaginal ultrasonography (TV Us) being considered as the gold standard for the CL assessment.Methods: A cohort of women with singleton pregnancies, and confirmed gestational age by first or early second trimester ultrasonography, last menstrual period & clinical assessment were selected to undergo transvaginal and transabdominal sonographic measurement of cervical length between 16 and 34 week gestation. Cervical length was first measured by transabdominal route (TAS) using a 3.5 MHz curved electronic array transducer with the patient in the supine position and with a full bladder, transvaginal sonography (TVS) was done by a 7.5 MHz probe attached to an ultrasound machine. The probe was covered with a latex condom and gel placed between the transducer and the cover and also on the surface. It was then gently inserted in the vagina to obtain a sagittal view of the cervix. Doppler measurement were taken by both transabdominal and transvaginal route.Results: Gradual decrease in cervical length is seen with advancement of gestation weeks. TA Us cervical length values are noted higher than TV Us however significance is seen only at 24 weeks and cervical width are showing gradual increase with advancement of gestation weeks without significant difference between them. The study compared the mean spectral Doppler parameters RI, PI and S/D Ratio at different weeks & observed that TV Us values are more at each gestation weeks than TA Us showing significant difference 24 weeks onwards.Conclusions: Although discrepancy in statistical significance, short cervical length, funneling and gland area are important to recognize for prediction of premature onset of labour, owing to the potential for perinatal morbidity and mortality and socioeconomic burden. Transvaginal sonography remains the dominant imaging modality for evaluation of the cervix. It is operator dependent modality so care should be taken to evaluate each morphologic character.