Although several measures of obsessive-compulsive (OC) symptoms exist, most are limited in that they are not consistent with the most recent empirical findings on the nature and dimensional structure of obsessions and compulsions. In the present research, the authors developed and evaluated a measure called the Dimensional Obsessive-Compulsive Scale (DOCS) to address limitations of existing OC symptom measures. The DOCS is a 20-item measure that assesses the four dimensions of OC symptoms most reliably replicated in previous structural research. Factorial validity of the DOCS was supported by exploratory and confirmatory factor analyses of 3 samples, including individuals with OC disorder, those with other anxiety disorders, and nonclinical individuals. Scores on the DOCS displayed good performance on indices of reliability and validity, as well as sensitivity to treatment and diagnostic sensitivity, and hold promise as a measure of OC symptoms in clinical and research settings.

Attentional bias toward negative social cues is thought to serve an etiological and/or maintaining role in social anxiety disorder (SAD). The current study tested whether training patients to disengage from negative social cues may ameliorate social anxiety in patients (N = 36) with a primary diagnosis of generalized SAD. Patients were randomly assigned to either an attention training condition (n = 18), in which patients completed a modified dot-probe task designed to facilitate attentional disengagement from disgusted faces, or a control dot-probe task condition (n = 18). As predicted, patients in the attention training condition exhibited significantly greater reductions in social anxiety and trait anxiety, compared with patients in the control condition. At termination, 72% of patients in the active treatment condition, relative to 11% of patients in the control condition, no longer met Diagnostic and Statistical Manual of Mental Disorders (4th ed.) criteria for SAD. At 4-month follow-up, patients in the attention training condition continued to maintain their clinical improvement, and diagnostic differences across conditions were also maintained. Results support attention-based models of anxiety and suggest that attention training is a promising alternative or complementary intervention.

Amazon.com's Mechanical Turk (MTurk) website provides a data collection platform with quick and inexpensive access to diverse samples. Numerous reports have lauded MTurk as capturing high-quality data with an epidemiological sample that is more representative of the U.S. population than traditional in-person convenience samples (e.g., undergraduate subject pools). This benefit, in combination with the ease and low-cost of data collection, has led to a remarkable increase in studies using MTurk to investigate phenomena across a wide range of psychological disciplines. Multiple reports have now examined the demographic characteristics of MTurk samples. One key gap remains, however, in that relatively little is known about individual differences in clinical symptoms among MTurk participants. This paper discusses the importance of assessing clinical phenomena in MTurk samples and supports its assertions through an empirical investigation of a large sample (N = 1,098) of MTurk participants. Results revealed that MTurk participants endorse clinical symptoms to a substantially greater degree than traditional nonclinical samples. This distinction was most striking for depression and social anxiety symptoms, which were endorsed at levels comparable with individuals with clinically diagnosed mood and anxiety symptoms. Participants' symptoms of physiological anxiety, hoarding, and eating pathology fell within the subclinical range. Overall, the number of individuals exceeding validated clinical cutoffs was between 3 and 19 times the estimated 12-month prevalence rates. Based on the current findings, it is argued that MTurk participants differ from the general population in meaningful ways, and researchers should consider this when referring to this sample as truly representative. (PsycINFO Database Record

Discovered and crystallized over sixty years ago, serotonin's important functions in the brain and body were identified over the ensuing years by neurochemical, physiological and pharmacological investigations. This 2008 M. Rapport Memorial Serotonin Review focuses on some of the most recent discoveries in serotonin that are based on genetic methodologies. These include examples of the consequences that result from direct serotonergic gene manipulation (gene deletion or overexpression) in mice and other species; an evaluation of some phenotypes related to functional human serotonergic gene variants, particularly in SLC6A4, the serotonin transporter gene; and finally, a consideration of the pharmacogenomics of serotonergic drugs with respect to both their therapeutic actions and side effects. The serotonin transporter (SERT) has been the most comprehensively studied of the serotonin system molecular components, and will be the primary focus of this review. We provide in-depth examples of gene-based discoveries primarily related to SLC6A4 that have clarified serotonin's many important homeostatic functions in humans, non-human primates, mice and other species.