We describe an integrated proteome database, termed Yonsei Proteome Research Center Proteome Database (YPRC-PDB) which can store, retrieve and analyze various information including two-dimensional electrophoresis (2-DE) images and associated spot information that were obtained during studies of hepatocellular carcinoma (HCC). YPRC-PDB is also designed to perform as a laboratory information management system that manages sample information, clinical background, conditions of both sample preparation and 2-DE, and entire sets of experimental results. It also features query system and data-mining applications, which are amenable to automatically analyze expression level changes of a specific protein and directly link to clinical information. The user interface is web-based, so that the results from other laboratories can be shared effectively. In particular, the master gel image query is equipped with a graphic tool that can easily identify the relationship between the specific pathological stage of HCC and expression levels of a potential marker protein on the master gel image. Thus, YPRC-PDB is a versatile integrated database suitable for subsequent analyses. The information in YPRC-PDB is updated easily and it is available to authorized users on the World Wide Web (http://yprcpdb.proteomix.org/ approximately damduck/).

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In this paper, an e-PBL model and problems for an effective computer education were developed and applied for information literacy education of computer in elementary schools. In order to progress an effective e-PBL class, a support learning system including an e-mentoring and a web discussion function has to be built. In this paper, we developed the e-PBL teaching model for information literacy education of computer in elementary schools and inspected its effectiveness and validity. In order to resolve the research questions, class elements were extracted from an analysis of the prior research in the e-PBL. The class elements in the e-PBL were analyzed to six elements of the 'unstructured practical problem', 'learner-centered problem', 'process reflected problem', 'cooperative learning reflected problem', 'on-line learning support system', and 'e-mentoring'. The e-PBL model was designed based on the extracted elements. The model developed by the present research added an on-line element and an e-mentoring element to the conventional PBL model. The main learning steps were given by 6 steps and it was characterized that the e-PAS system (Learning support system) and e-mentoring were used. The main steps include an introducing step, a problem proposing step, a problem solving plan step, a problem solving step, a result proposing and presenting step, a class finishing step, and an evaluation step. For the successful e-PBL teaching in elementary education of computer, the learning system that has the various learning strategies and support systems and interacts teachers with learners frequently will ought to be built.

Cooperative learning is one of main methods to achieve the educational goal of problem-solving and decision-making