Summary Maternofetal transmission of cytomegalovirus (CMV) is the most common infectious cause of congenital malformation in developed countries. Maternal infection often results from close contact with infected children, and this may occur in day care centres (DCCs). A systematic review of observational studies was conducted to examine the prevalence of CMV infection among children attending DCCs. Meta‐analysis using the random effect model was performed for studies including controls. Sources included PubMed, EMBASE (until August 2018), and references from identified publications. Inclusion criteria were studies reporting CMV infection prevalence among childcare children aged less than 7 years of age. Controls were children without childcare exposure. CMV infection was defined as viral excretion detected by culture, polymerase chain reaction, or CMV seropositivity. Twenty‐eight publications including 8347 participants met the eligibility criteria. The pooled prevalence of CMV infection among children in childcare from all studies was 32% (95% CI 23‐41). Within case‐controlled studies, prevalence among children attending DCCs was 34% (95% CI 25‐44), whereas prevalence among those without childcare exposure was 22% (95% CI 15‐30). Meta‐analysis showed a significant association between DCC attendance and CMV infection (odds ratio 2.69, 95% CI 1.68‐4.30; heterogeneity χ2/df = 8; I2 = 84%, P < 0.00001). Attendance at DCCs is significantly associated with increased risk of childhood CMV infection. Prevention strategies to reduce risk of CMV infection of pregnant women and children should involve review of DCC exposure and consideration of preventative hygiene strategies.

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premature (age ,60 years) coronary artery disease (CAD). However, their awareness remains low in hospital settings. Selective screening of patients admitted with premature CAD is important as it can alter the management plan post discharge. Objectives: We aim to describe the frequency of FH and raised Lp(a) amongst patients admitted with premature CAD. Methods: Using the Dutch Lipid Clinic Network Score (DLCNS), we collected data [including testing for Lp(a)] from patients admitted with acute coronary syndrome over a two-month period at a tertiary hospital in Western Australia. Results: A total of 114 patients were admitted with premature CAD during this period with male preponderance (70.2% males vs 29.8% females, p,0.05). The point prevalence of probable/definite FH was 18.4% and 43.9% with "possible FH". Of the 18.4% with probable/definite FH, twothirds had an untreated LDL-C of 4 mmol/L and 42.9% with LDL-C 5mmol/L. Amongst those with LDL-C of 3.9 mmol/L or less, 37.2% had raised Lp(a) of 0.3 g/L or more and amongst them, 21.1% had Lp(a) of 0.5 g/L or more. Conclusions: FH and raised Lp(a) remain prevalent amongst patients with premature CAD. Selective screening in these patients provides clinicians the opportunity to devise specific management plan including initiating cascade screening in patients with FH.