Objective : To observe and describe the clinical effects of propranolol in an agitated and violent patient with postviral encephalitis organic personality disorder. Background: Cognitive and behavioral deficits are common in patients with viral encephalitis. Methods to modify behavior by a behavior program and medication have reported limited success. Case: A sixteen-year-old girl developed progressive violent and sexually disinhibited behavior five weeks following acute viral encephalitis (presumed herpes simplex encephalitis). Three weeks of high dose lorazepam (6mg/d) failed to control her symptoms. Intensive behavioral therapy was also ineffective and violent behavior increased during structured treatment hours. Benzodiazepines and low dose haloperidol were ineffective over the subsequent two weeks in a neurorehabilitation unit. Propranolol was then given (10 mg b.i.d. to 20 mg t.i.d.) and she had a dramatic change in behavior with less violence and less agitation after one day of treatment with propranolol. Her short-term memory improved. Decreased dosage of propranolol was associated with the return of violent behavior. Maintenance propranolol was effective in controlling her symptoms and led to the resumption of her multidisciplinary rehabilitation program. Conclusion: Violent and autistic behavior due to viral (herpes) encephalitis may respond to propranolol.