We found that the HDSD regimen had a safety profile similar to that seen in previous studies. Although the differences were not statistically significant, clinical success rates for comparator were higher than for daptomycin. In post hoc analyses HDSD daptomycin performed better in some subgroups (e.g. outpatients) than in others (e.g. certain MRSA infections). These observations require confirmation in larger trials.

It is well known that spoken words can often be recognized from just their onsets and that older adults require a greater word onset duration for recognition than young adults. In this study, young and older adults heard either just word onsets, word onsets followed by white noise indicating the full duration of the target word, or word onsets followed by a low-pass-filtered signal that indicated the number of syllables and syllabic stress (word prosody) in the absence of segmental information. Older adults required longer stimulus durations for word recognition under all conditions, with age differences in hearing sensitivity contributing significantly to this age difference. Within this difference, however, word recognition was facilitated by knowledge of word prosody to the same degree for young and older adults. These findings suggest, first, that listeners can detect and utilize word stress in making perceptual judgments and, second, that this ability remains spared in normal aging.

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Two experiments are reported that examined the temporal structure of recall for categorizable word lists by younger and older adults. All participants showed response bursting, in which recall order is clustered by semantic category, with longer interresponse times (IRTs) appearing between categories than within categories. Experiment 1 demonstrated that older adults, even when matched to younger adults in overall accuracy, differed in the rate of increase of between-category IRTs with output position, but not in within-category IRTs. Experiment 2 showed that this interaction is eliminated when the names of the response categories are provided to the participants. Results are interpreted in terms of combined effects of an age-compromised episodic memory system (between-category IRTs) accompanied by a comparatively preserved semantic system (within-category IRTs) in healthy aging.