Investigations on the hemodynamic changes of the venous system of patients with multiple sclerosis (MS) have contradictory results. In this study, the biomechanical parameters of the internal Jugular vein (IJV) and common carotid artery (CCA) of MS patients were extracted and compared to healthy individuals. Methods: B-mode and Doppler sequential ultrasound images of 64 IJV and CCA of women including 22 healthy individuals, 22 RRMS (Relapsing-Remitting Multiple Sclerosis) patients, and 20 PPMS (Primary-Progressive Multiple Sclerosis) patients were recorded and processed. Biomechanical parameters of the IJV and the CCA walls were extracted and calculated in three cardiac cycles. Results:The maximum and the minimum pressures (IJV) were 31% and 19% in RRMS patients and 39% and 24% in PPMS patients more than healthy subjects. The venous wall thicknesses in RRMS and PPMS patients were 51% and 60% higher compared to healthy subjects, respectively. IJV distensibility in RRMS and PPMS patients were 70% and 75% and compliance were 40% and 59% lower compared to healthy subjects. The maximum intima-media thicknesses (CCA) were 38% and 24% and the minimum intima-media thicknesses were 27% and 23% higher in RRMS and PPMS patients compared to healthy individuals, respectively. The shear modulus of CCA walls in RRMS and PPMS patients were17% and 31%, and radial elastic moduli were 47% and 9% higher compared with healthy individuals. Conclusion:It is concluded that there are significant differences between some physical and biomechanical parameters of CCA and IJV in MS patients and healthy individuals.