Low socioeconomic status (SES) is one of the strongest predictors of morbidity and premature mortality worldwide, as well being associated with large increases in cardiovascular disease in both men and women. Uncontrolled hypertension contributes to cardiovascular disparity. Non-adherence to antihypertensive regimens worsens the cardiovascular burden and further widens the health disparity gap. A hierarchical multiple regression study of multiple factors impacting adherence among urban residents in a New York metropolitan region found socioeconomic factors as the strongest factors impacting adherence in this cardiovascular high-risk population.. Methods Secondary analysis of data of a cross-sectional, correlation design study of a dissertation study, with each of the SES variables analyzed against adherence and self-efficacy variables. Results Overall, only three SES variables (years with the same provider, work status and income) were significantly related to adherence and/ or self-efficacy. Years with the same provider was related to adherence with correlation of rs=0.16 (p=0.048), and to self-efficacy rs=2.0 (p=0.016). Work status was related to adherence with difference in adherence scores between retired and unemployed subjects (KS=38.6, p=0.013 with Bonferroni adjustment; means=3.7 and 3.3, respectively). Work status was not related to selfefficacy scores. Income level was significantly related to the self-efficacy scores, but not the adherence scores.