In this report, we present the regularization results of displacement vector measurement by the multidimensional cross-spectrum phase gradient method (MCSPGM), multidimensional autocorrelation method (MAM), and multidimensional Doppler method (MDM) without lateral modulation. In addition to the results of spatially variant regularization in displacement vector measurement using displacement variances, the results of displacement component-dependent regularization are presented. That is, according to the measurement accuracy of displacement components, the regularization is properly applied to the respective displacement components. For instance, only the regularization on the lateral displacement is effective. That is, for the lateral nonmodulation case, the accuracies and stabilities of lateral/elevational displacement measurements significantly increase. In conjunction, the convergence speed of phase matching also increases. The demonstrated measurements of the displacement vector distributions in experiments using inhomogeneous shear modulus agar phantoms confirm that displacement-componentdependent regularization enables better strain tensor measurement and shear modulus reconstruction from the viewpoints of accuracy and stability. The contrast-to-noise ratio (CNR) is useful to set regularization parameters properly for the displacement regularization, whereas the CNR is useless for shear modulus regularization in the sense that the accuracy of reconstruction value cannot be evaluated.

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Visceral leishmaniasis (VL) is caused by parasitic protozoa of the genus Leishmania and is characterized by clinical manifestations such as fever, hepatosplenomegaly and anemia. Hemophagocytosis, the phenomenon of phagocytosis of blood cells by macrophages, is found in VL patients. In a previous study we established an experimental model of VL, reproducing anemia in mice for the first time, and identified hemophagocytosis by heavily infected macrophages in the spleen as a possible cause of anemia. However, the mechanism for parasite-induced hemophagocytosis or its role in parasite survival remained unclear. Here, we established an in vitro model of Leishmania-induced hemophagocytosis to explore the molecules involved in this process. In contrast to naïve RAW264.7 cells (mouse macrophage cell line) which did not uptake freshly isolated erythrocytes, RAW264.7 cells infected with L. donovani showed enhanced phagocytosis of erythrocytes. Additionally, for hemophagocytes found both in vitro and in vivo, the expression of signal regulatory protein α (SIRPα), one of the receptors responsible for the ‘don’t-eat-me’ signal was suppressed by post-transcriptional control. Furthermore, the overlapped phagocytosis of erythrocytes and Leishmania parasites within a given macrophage appeared to be beneficial to the parasites; the in vitro experiments showed a higher number of parasites within macrophages that had been induced to engulf erythrocytes. Together, these results suggest that Leishmania parasites may actively induce hemophagocytosis by manipulating the expression of SIRPα in macrophages/hemophagocytes, in order to secure their parasitism.

Complete band offset characterization of the HfO 2 / SiO 2 / Si stack using charge corrected x-ray photoelectron spectroscopy Electron transfer reactions on Cs/MoS 2 (0002) with chlorine, oxygen, and water: High resolution x-ray photoelectron spectroscopy and theoretical study

A decade after the 2011 Tohoku-oki earthquake (Mw 9.0), geological surveys were conducted at multiple sites along the Pacific Coast of the tsunami-inundated Tohoku region in Japan, providing thousands of years of tsunami history. However, the challenges of correlation between historical records and geological tsunami deposits and identifying sources of historical and paleotsunamis have newly surfaced. Particularly the simultaneity and source of the 1611 Keicho tsunami in the Tohoku region and the seventeenth-century tsunami in the Hokkaido region are problematic. To solve such major issues, we conducted a tsunami-deposit survey at Sekinehama on the north coast of Shimokita Peninsula, near the junction of the Japan and Kuril trenches. We performed nondestructive analyses (X-ray computed tomography and micro-X-ray-fluorescence core scanning), grain-size analysis, tephra analysis, and radiocarbon dating of sediments from two coastal outcrops and inland drill cores. We identified five tsunami deposits (TD1–TD5) during the last 6 kyr and correlated them at a 200–400 m distance from the coast. They also correlate with previously identified tsunami deposits around the Shimokita Peninsula. From our study on tsunami deposits, we found other washover deposits in the coastal outcrops that are not represented in the inland cores. These indicate minor washover events related to small tsunamis and infrequent storm surges. The modeled age of the latest tsunami deposit is 500–300 cal yr BP (1450–1650 cal CE). This either correlates with two known tsunamis (the 1611 Keicho tsunami and another seventeenth-century tsunami) or is a previously unknown tsunami that occurred in the fifteenth–seventeenth centuries. If the latest tsunami deposit is to be accurately correlated with tsunami deposits previously identified within a 50-km distance from the study site, we need to consider an unknown fifteenth-century tsunami. Our investigation yields insights regarding the tsunami source in the vicinity of the junction of the Japan and Kuril trenches.