Hypokalaemia presenting as quadriplegia is common, but association with renal tubular acidosis and Sjogren's syndrome is a rare entity. We present a case of 35-year-old female admitted with acute onset quadriplegia with dysphagia for solids and parotid enlargement with normal anion gap metabolic acidosis. CT-abdomen showed bilateral renal stone disease and high positivity of autoantibody (SS-A)/anti Ro and histopathology of minor salivary gland showed lymphocytic infiltrations suggestive of immune mediated destruction of salivary gland meeting the American-European Consensus Classification Criteria of primary Sjogren's syndrome. Patient was managed appropriately with correction of hypokalaemia and acidosis and recovered completely three days after admission.