Diclofenac is a widely used non-steroidal anti-inflammatory drug (NSAID). The most common reported adverse drug reactions (ADRs) of diclofenac are nausea, vomiting, epigastric pain, headache and dizziness. Fixed drug eruption (FDE) is also one ADR due to diclofenac, which is even though not uncommon, in this case the severity is very high. That has made us to focus on this case. A 52-year-old male patient attended the skin OPD (outpatient department) with multiple erythematous patches over face, neck, upper limbs and lower limbs which were started after taking diclofenac for sprain injury. After complete history, the patient said he had similar complaints in the past for same drug. Patient started showing improvement after stopping diclofenac. Completely recovered after 10 days.