[figure: see text] A novel benzyloxyaniline linker that uses ceric ammonium nitrate (CAN) as a cleavage reagent is described. Its application in the solid-phase synthesis of N-unsubstituted beta-lactams and secondary amides furnishes compounds in moderate to excellent yield (45-91%) and high purity (93-99%).

Solid phase organic synthesis is a rapidly expanding area of synthetic chemistry which is being widely exploited in the search for new biologically active compounds by combinatorial techniques. This review introduces the key concepts of solid phase methodology and combinatorial synthesis with particular focus on the issues that concern the development of linkers which are used to attach the substrate to the solid support.

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