A current report expresses that Orange Peel Extract use as catalyticmedium for the synthesis of Indoloquinoxaline derivatives from commercially available starting materials. Isatin and O-phenylenediamine in presence of fresh orange peel extractresulted into desired product at room temperature in a given reaction condition. Advantages of this method include greener and cleaner conditions, shorter reaction time, and good to moderate yield of products. A simple one-pot procedure has been developed for the synthesis of Indoloquinoxaline derivatives from readily available starting materials.