Staphylococcus aureus is a non motile, non spore- forming gram positive bacterium that causes a wide range of infections such as endocardatis, skin infections, bacteraemia, sepsis and food poisoning. The objective of this study is to evaluate the pattern of drug resistance of staphylococcus aureus in different type of samples that were taken from different wards (emergency and OPD) of the hospital. In this study we analyzed 40 isolates were obtained on blood agar and tryptic soy agar. Identification of the isolates was carried out by catalase test as well as methicillin resistance. Confirmed staphylococcus aureus isolates were analyzed for antimicrobial susceptibility testing. In our study the isolates from patients, particularly are frequently resistance to multiple antimicrobial agents more than 90% of staphylococcus aureus isolates were resistance to cefalothin, erythromycin and 80% are resistance to vancomycin. Our findings showed that MRSA isolates were coming from the community as indicated by hospital ward types, that even with no prolonged hospital stays the patients coming from the community were carrying MRSA strains.