The evidence base for organ-protective intensive care is weak; most of the available evidence is on the level of expert opinion. There is good reason to believe, however, that the continuation of intensive care, in the sense of early donor management, can make organ transplantation more successful both by increasing the number of transplantable organs and by improving organ quality.

We report a case of severe neuroleptic malignant syndrome developing in a 28-year-old female patient following deliberate self-poisoning with atypical antipsychotic drugs and serotonin reuptake inhibitors. Because of an increasing loss of consciousness she was rapidly transferred to an Intensive Care Unit. Following this, she became progressively febrile associated with rhabdomyolysis and life-threatening organ dysfunctions. Due to fast diagnosis and immediate therapy the patient was treated successfully. This article describes etiology, pathophysiology and symptoms of neuroleptic malignant syndrome. In addition therapeutic options are discussed.

Die Transplantation von postmortal gespendeten Organen ist für Menschen mit irreversiblen Organversagen im Endstadium seit vielen Jahren eine lebensrettende und die Lebensqualität verbessernde Therapie 1 2 . Nicht zuletzt aufgrund fehlender Leitlinien ist das anästhesiologische Management bei der Organentnahme erschwert. Der Beitrag fasst die existierende Literatur zusammen und überprüft, ob evidenzbasierte Empfehlungen für das anästhesiologische Management abgeleitet werden können.

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