To investigate the lasting effects of high ozone concentrations under environmental conditions, we examined the respiratory health, pulmonary function, bronchial hyperresponsiveness to methacholine, allergic sensitization, and lymphocyte subpopulations of 10- to 14-yr-old children. A total of 218 children recruited from an area with high ozone concentrations (Group A) were tested against 281 children coming from an area with low ozone concentrations (Group B). As to subjective complaints, categorized as "usually cough with or without phlegm," "breathlessness," and "susceptibility to chest colds," there was no difference between the two groups. The lung function parameters were similar, but in Group A subjects' bronchial hyperresponsiveness occurred more frequently and was found to be more severe than in Group B (29.4 versus 19.9%, p less than 0.02; PD20 2,100 +/- 87 versus 2,350 +/- 58 micrograms, p less than 0.05). In both groups the number of children who had been suffering from allergic diseases and sensitization to aeroallergens, found by means of the skin test, was the same. Comparison of the total IgE levels showed no difference at all between the two groups. As far as the white blood cells are concerned, the total and differential cell count was the same, whereas lymphocyte subpopulations showed readily recognizable changes.(ABSTRACT TRUNCATED AT 250 WORDS)

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This article tracks the intergovernmental negotiations aimed at combatting human-induced greenhouse gas emissions under the United Nations Framework Convention on Climate Change from COP21 and the creation of the Paris Agreement in 2015 to COP24 in Katowice, Poland in 2018. These conferences are explored in detail, focusing on the Paris Rulebook negotiations around how to implement market- and nonmarket-based approaches to mitigating climate change, as set out in Article 6 of the Paris Agreement, and the tensions regarding the inclusion of negotiating text safeguarding human rights. A concluding section comments on the collapse of Article 6 discussions and the implications for climate justice and social quality for the Paris Agreement going forward.

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