The structure of a new pancreatic lipase inhibitor, lipstatin, produced by Streptomyces toxytridni was determined as (25, 35, 55,7Z, 1 0Z )-5-[(5' )-2-formamido-4-methylpentanoyloxy]-2-hexyl-3-hydroxy-7,10-hexadecadienoic lactone by spectroscopic and chemical methods.Structurally lipstatin is closely related to the knownesterase inhibitor esterastin. It contains a iV-formyl-L-leucine side chain instead of the iV-acetyl-L-asparagine in esterastin.

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