Developing a biomimetic material to wound care is an emerging need for the healing process. Poly (ε-caprolactone) (PCL) is a polymer with the necessary dressing’s requirements often used in medicine. Their surface, physic-chemical and biological properties can be modified by adding bioactive compounds, such as andiroba seed oil (Carapa guianensis). This Amazonian natural plant has medicinal and pharmacological properties. For this purpose, PCL polymeric films incorporated with andiroba oil were investigated. The synthesis of hybrids materials was carried out in the solvent casting method. Thermal properties were evaluated using thermogravimetric analysis (TGA/DTGA) and differential scanning calorimetry (DSC). The solvent type on the surface and hydrophilicity of samples was studied using a scanning electron microscope (SEM). Additionally, contact angle measurements, functional groups analysis, fluid absorption capacity, and cell viability were performed. The results demonstrated the influences of andiroba oil under the morphology and thermal properties of the polymeric matrix; the hydrophilicity of the hybrid film obtained by acetic acid was reduced by 13%; the porosity decreased as the concentration of oil increased, but its higher thermal stability. The L929 cell line’s proliferation was observed in all materials, and it presented nontoxic nature. It was demonstrated the ability of PCL hybrid film as a matrix for cell growth. Then, the materials were proved potential candidates for biomedical applications.

In the last decades, the eCB system has been highlighted by its neuro and immunomodulatory effects. Beyond CB1R effects in Central Nervous System (CNS), CB2R target drugs has been showed to be promising to mitigation of neuroinflammatory diseases in mouse models. However, it remains unknow the effects of CB2R target drugs on behavior. Therefore, we review the effects of CB2R on behavior in murine models by Pubmed website, selecting studies between 2001 to 2021. In this sense, many studies has demonstrated the effects of overexpression, lack, activation or antagonization of CB2R on Aggressive behavior, Memory-associated behaviors, Mood disorders and Reward behavior. Similarly, it is not clear yet how the eCB system modulates the behavior through CB2Rs present in neurons. Thus, in mouse models, although the pharmacological treatment with CB2R target drugs seems to be promising for neuroinflammatory diseases, on behavior there are few answers about the pathways of this modulation, as well as, it is fundamental the development and/or the update of behavioral tests that evaluate many parameters, then expose better interpretations in these tests.