Background: COVID-19 continues to ravage the world with economies and life significantly and negatively affected. Fortunately, there has been significant progress in the production of vaccines to stem the infection. However, with controversies and myths surrounding vaccinations, it is timely to examine individuals’ willingness to vaccinate. The present study developed and validated the Motors of COVID-19 Vaccination Acceptance Scale (MoVac-COVID19S) and assessed the acceptance of COVID-19 vaccination utilizing the cognitive model of empowerment (CME). Methods: A total of 3145 university students (mean age=20.80 years; SD=2.09) were recruited for the present study between January 5 and 16, 2021. Two MoVac-COVID19S scales (9-item and 12-item) were adapted from the MoVac-Flu Scale, an instrument developed using CME. Psychometric tests were conducted to ascertain reliability and validity properties. Results: The findings indicated that the MoVac-COVID19S had high internal consistency in both the 9-item version (ω=0.921) and 12-item version (ω=0.898). The factor structure of the MoVac-COVID19S (9-item and 12-item versions) corresponded well with CME theory. All the fit indices were satisfactory (CFI=0.984, TLI=0.971, RMSEA=0.088, SRMR=0.058) but the 9-item MoVac-COVID had better fit indices than the 12-item MoVac-COVID due to the negative wording effects existing in the 12-item MoVac-COVID19S. The scale had satisfactory known-group validity in both 9-item and 12-item versions. Conclusions: The MoVac-COVID19S has promising psychometric properties based on internal consistency, factor structure, and known-group validity.